Windows cannot access the specified device, path, or file. You may not have the appropriate permission to access the item. Looks familiar to you when you are installing a new software or in Deltek GCS Premier service patch upgrade? This is because of security implementation in Microsoft Windows 2003 Server. Very easy to solve this problem. All you have to do is select the file you want to run, right click on, then select properties. In General tab, scroll down and you will see Security : This file came from another computer and might be blocked to help protect this computer . Click on Unblock . Click OK Now, run the file again by double clicking, and it should work for you. Assuming that you have administrative permission to install a new software to this computer.